Replication timing quantitative trait loci

Replication timing quantitative trait loci (or rtQTL) are genetic variations that lead to differential use of replication origins, exhibiting allele-specific effects on replication timing. Originally, 16 rtQTL were identified in an analysis of human genomes.

References

• Koren, Amnon, Polak Paz, Nemesh James, Michaelson Jacob J, Sebat Jonathan, Sunyaev Shamil R, McCarroll Steven A, Dec 2012, Differential relationship of DNA replication timing to different forms of human mutation and variation, Am. J. Hum. Genet., 91, 6, 1033–40, United States, 23176822, 10.1016/j.ajhg.2012.10.018, 3516607
• 25416942, 4359889, 2014, Koren, A., Genetic variation in human DNA replication timing, Cell, 159, 5, 1015–1026, Handsaker, R. E., Kamitaki, N., Karlić, R., Ghosh, S., Polak, P., Eggan, K., McCarroll, S. A., 10.1016/j.cell.2014.10.025